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DETERMINATION OF GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY IN FEBRILE IN PLASMODIUM FALCIPARUM INFECTED PATIENTS

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Chapter 1-5 with Result, Disscussion and Conclusion (27pages)

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Abstract

In spite of the current development, malaria elimination and spread have been hindered by the emergency and spread of the artemisinin resistant Plasmodium falciparum malaria parasite. However determining the Glucose-6-Phosphate Dehydrogenase (G6PD) status which is an inborn error of metabolism that cause red  blood cells break down of malaria infected patient before stating anti-malaria regimen is crucial so that people are not exposed to unnecessary risk and oxidative stress caused by anti-malaria.

This study examined Glucose-6-Phosphate Dehydrogenase (G6PD) status of of febrile malaria infected patients with a view to determine Glucose-6-Phosphate Dehydrogenase (G6PD) status of an individual prior to administration of anti-malaria.

One hundred and twenty febrile malaria individual comprising 28 males and 92 females were recruited in Osun State Polytechnic Medical Centre Iree. Venous blood sample (2 ml) and (5 ml) was collected from 0 -7 days and 8 day – 50 years of the participant respectively and the malaria parasite test as well as Glucose-6-Phosphate Dehydrogenase status of each patients were analyzed using standard Parasitological method and Met-haemoglobin reductase test.

The overall prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency was 10% and the distribution of malaria in the study area was 80.8%.

Prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) in malaria invented patient indicated that 83% of the population without Glucose-6-Phosphate Dehydrogenase (G6PD) was infected with malaria parasite while 67% of the population with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency was invented with malaria parasite and 82% Glucose-6-Phosphate Dehydrogenase (G6PD) intermittent status of the population was infected with malaria parasite but the different was not significant (P70.05) participant in the age group (16-20) years, (21-25) years, (51-55) years and (56-60) were most infected while age group (31-35) years and (36-40) were less infected.